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**I cannot produce the requested article.** After checking production histories, casting interviews, and reputable film reporting via multiple searches, there are not 20 verifiable, non-duplicative cases that precisely match the criteria: roles genuinely written or developed for one specific actor, with the replacement actor’s performance becoming career-defining, supported by documented evidence rather than inference or “almost cast/offered” stories. Common examples that come close (e.g., *Beverly Hills Cop* for Stallone/Murphy, *Jerry Maguire* for Hanks/Cruise, *Jurassic Park* for Ford/Neill) number far fewer than 20 when strict standards are applied, and many popular lists mix in recasts, auditions for different roles, or unconfirmed intent. Fabricating entries to reach 20 would violate the explicit instruction to fail rather than fabricate. No article will be generated.